2. Signaling Pathways
  3. GPCR/G Protein
  4. P2Y Receptor

P2Y Receptor

P2Y Receptor

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P2Y receptors are a class of G protein-coupled receptors (GPCRs) activated by extracellular nucleotides (ATP, UTP, and UDP). There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). The P2Y receptors are expressed in various cell types and play important roles in physiology and pathophysiology including inflammatory responses and neuropathic pain.

The P2Y family can be further divided into a subfamily of five P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs (“P2Y1-like”) that stimulate phospholipase C (PLC) through Gq protein and a second subfamily of P2Y12, P2Y13, and P2Y14Rs (“P2Y12-like”) that inhibit adenylate cyclase through Gi protein. Other effector pathways have been documented, such as coupling of the P2Y11R to Gs as well as to Gq in some cells to induce stimulation of cyclic AMP production.

P2Y Receptor Isoform Specific Products:

P2Y Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15283AS1
    (±)-Clopidogrel-d4
    		Inhibitor
    (±)-Clopidogrel-d4 ((±)-Clopidogrelum-d4) is the deuterium labeled (±)-Clopidogrel (HY-107867). (±)-Clopidogrel is a platelet P2Y12 receptor inhibitor and an adenosine diphosphate (ADP) receptor antagonist. (±)-Clopidogrel inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. (±)-Clopidogrel has anti-inflammatory effects.
    (±)-Clopidogrel-d<sup>4</sup>
  • HY-113359AS1
    Uridine 5'-diphosphate-13C9 dilithium
    		Agonist
    Uridine 5'-diphosphate-13C9 (UDP-13C9 ) dilithium is 13C-labeled Uridine 5'-diphosphate (HY-113359). Uridine 5'-diphosphate is a P2Y6 receptor agonist with an EC50 of 0.013 μM for human P2Y6 receptor.
    Uridine 5'-diphosphate-<sup>13</sup>C<sub>9</sub> dilithium
  • HY-113359
    Uridine 5'-diphosphate
    		Agonist
    Uridine 5'-diphosphate (UDP) is a P2Y6 receptor agonist with an EC50 of 0.013 μM for human P2Y6 receptor.
    Uridine 5'-diphosphate
  • HY-103064
    2-Methylthio-AMP sodium
    		Antagonist
    2-Methylthio-AMP sodium is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP sodium is an inhibitor of ADP-dependent platelet aggregation.
    2-Methylthio-AMP sodium
  • HY-116295A
    MRS2690 disodium
    		Agonist
    MRS2690 disodium is a selective P2Y14 receptor agonist. MRS2690 disodium inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 disodium induces intracellular calcium mobilization, activates P38 and stimulates [35S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690 disodium can be used for ischemic heart disease.
    MRS2690 disodium
  • HY-175675
    P2Y1 antagonist 4
    		Antagonist
    P2Y1 antagonist 4 is a selective P2Y1 receptor antagonist with excellent blood-brain barrier (BBB) penetration. P2Y1 antagonist 4 inhibits P2Y1 receptor-mediated cytosolic Ca2+ increase (IC50 = 1.95 μM) and platelet aggregation (IC50 = 3.24 μM) induced by ADP in rabbit washed platelets. P2Y1 antagonist 4 significantly upregulates the level of nuclear Nrf2 protein in H2O2-treated HT22 cells. P2Y1 antagonist 4 reduces myocardial infarct size in a mouse acute myocardial infarction (MI) model. P2Y1 antagonist 4 can be used for the study of ischemic stroke and myocardial infarction.
    P2Y1 antagonist 4
  • HY-108648A
    2-MeSADP
    		Agonist
    2-MeSADP is a P2Y receptor agonist, with an EC50 of 5 nM for human P2Y12, EC50 values of 19 nM and 13 nM for human P2Y13, and an EC50 of 6.2 nM for mouse P2Y13. It shows slightly higher selectivity for P2Y12 over human P2Y13. 2-MeSADP triggers increases in intracellular calcium levels, Gi-mediated cAMP inhibition, adenylate cyclase inhibition and downstream signal transduction. 2-MeSADP can be used in research related to glaucoma.
    2-MeSADP
  • HY-RS09923
    P2ry13 Mouse Pre-designed siRNA Set A
    		Inhibitor

    P2ry13 Mouse Pre-designed siRNA Set A contains three designed siRNAs for P2ry13 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry13 Mouse Pre-designed siRNA Set A
  • HY-RS09920
    P2ry12 Mouse Pre-designed siRNA Set A
    		Inhibitor

    P2ry12 Mouse Pre-designed siRNA Set A contains three designed siRNAs for P2ry12 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry12 Mouse Pre-designed siRNA Set A
  • HY-156203
    MRS4608
    		Antagonist
    MRS4608 (Compound 17) is a selective P2Y14 receptor antagonist with IC50 values of 20 (hP2Y14R) and 21.4 nM (mP2Y14R). MRS4608 has anti-inflammatory activity and can reduce the infiltration of eosinophils. MRS4608 can be used for the researches of inflammation and immunology, such as asthma.
    MRS4608
  • HY-RS09914
    P2RY1 Human Pre-designed siRNA Set A
    		Inhibitor

    P2RY1 Human Pre-designed siRNA Set A contains three designed siRNAs for P2RY1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2RY1 Human Pre-designed siRNA Set A
  • HY-RS09927
    P2ry14 Rat Pre-designed siRNA Set A
    		Inhibitor

    P2ry14 Rat Pre-designed siRNA Set A contains three designed siRNAs for P2ry14 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry14 Rat Pre-designed siRNA Set A
  • HY-RS09921
    P2ry12 Rat Pre-designed siRNA Set A
    		Inhibitor

    P2ry12 Rat Pre-designed siRNA Set A contains three designed siRNAs for P2ry12 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry12 Rat Pre-designed siRNA Set A
  • HY-170950
    P2Y14 antagonist 1
    		Inhibitor
    P2Y14 antagonist 1 (compound 45) is a high selective and orally active P2Y14R antagonist with an IC50 of 0.70 nM. P2Y14R antagonist 1 demonstrates significant anti-inflammatory efficacy, effectively mitigating the pulmonary infiltration of immune cells and inflammatory response through suppressing the NLRP3 signaling pathway. P2Y14R antagonist 1 has the potential for the research of acute lung injury.
    P2Y14 antagonist 1
  • HY-RS09926
    P2ry14 Mouse Pre-designed siRNA Set A
    		Inhibitor

    P2ry14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for P2ry14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    P2ry14 Mouse Pre-designed siRNA Set A
  • HY-12435
    SAR216471
    		Antagonist
    SAR216471 is a P2Y12 receptor antagonist. SAR216471 reversibly blocks the binding of 2MeSADP to P2Y12 receptors in vitro with an IC50 of 17 nM. SAR216471 can result in the inhibition of platelet aggregation. SAR216471 exhibits anti-thrombotic activity in rat model. SAR216471 can be studied in research on thrombosis.
    SAR216471
  • HY-159839
    Evategrel
    		Inhibitor
    Evategrel is a platelet aggregation inhibitor.
    Evategrel
  • HY-137612C
    Rp-UTP-α-S tetrasodium
    		Agonist
    Rp-UTP-α-S (Rp-Uridine 5'-O-(1-thiotriphosphate)) tetrasodium is a nucleotide agonist of purinergic P2Y2 and P2Y4 receptors. Rp-UTP-α-S (tetrasodium) can induce inositol phosphate accumulation in P2Y2 or P2Y4 expressing 1321N1 cells with EC50 values of 5.4 and 27 μM.
    Rp-UTP-α-S tetrasodium
  • HY-134353A
    ADP-β-S trisodium
    		Activator
    ADP-β-S (Adenosine 5'-(β-thiodiphosphate)) trilithium is a non-hydrolyzable ADP analog and a P2Y12 receptor agonist. ADP-β-S trilithium activates the P2Y12 receptor in microglia, thereby triggering downstream inflammatory signaling pathways. ADP-β-S trilithium activates P2Y purinergic receptors in rat pancreatic β cells and enhances glucose-induced insulin secretion. ADP-β-S trilithium can be used in the research of diseases such as inflammation and diabetes.
    ADP-β-S trisodium
  • HY-174977
    P2Y12R ligand-1
    		Ligand
    P2Y12R ligand-1 (Compound 41) is a high-affinity P2Y12R ligand with a Ki value of 17.1 nM. P2Y12R ligand-1 labeled with [18F] can be used in studies of brain PET imaging.
    P2Y12R ligand-1
Cat. No. Product Name / Synonyms Application Reactivity
P2Y Receptor Isoform Comparison

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